Aug 16, 2025 · * The application uses the Fib4 score formula. performed a cross-sectional study to determine the diagnostic utility of FIB-4 scores in a large, diverse population with NAFLD over time. Your FIB-4 result shows your risk of liver disease. Regeln: Bei einem FIB4-Score ≤ 1,30 (< 2,0 bei Patienten mit 65 Jahren und älter) wird ein niedrigeres Risiko für eine Leberfibrose angenommen und abhängig vom klinischen Risiko eine Kontrollbestimmung des FIB4-Tests in 2-5 Jahren empfohlen. Bei Patienten mit nichtalkoholischer Fettleber helfen deutsche Leitlinien nur bedingt weiter. Medical Necessity Aetna considers transient elastography (e. Für Patienten im Alter von ≤ 35 Jahren ist der FIB4-Score nur unter Vorbehalt beurteilbar. Atcha GP & Dr. Voraussetzung für die Anwendbarkeit des Scores ist allerdings die vorangegangene Diagnose einer NAFLD. Sep 1, 2024 · A stepwise approach using blood-based scores (such as FIB-4) and, sequentially, imaging techniques (such as transient elastography) is suitable to rule-out/in advanced fibrosis, which is predictive of liver-related outcomes. Aufgrund der einfachen Erhe-bung eignet sich der FIB4-Score gut zur Erhebung des Fibro erisikos auch außerhalb eines hepatolo-gischen Zentrums. The usage is only for medical purposes. FIB4-Score zum Screening auf nicht-alkoholische Fettlebererkrankung Sehr geehrte Frau Kollegin, sehr geehrter Herr Kollege, sehr geehrtes Praxisteam, Regeln: Bei einem FIB4-Score ≤ 1,30 (< 2,0 bei Patienten mit 65 Jahren und älter) wird ein niedrigeres Risiko für eine Leberfibrose angenommen und abhängig vom klinischen Risiko eine Kontrollbestimmung des FIB4-Tests in 2-5 Jahren empfohlen. Mar 1, 2022 · In a large, real-world cohort of patients with NAFLD, NASH, or at RISK of NASH, the FIB-4 score was the strongest independent predictor of MACE, beyond established cardiovascular risk factors and baseline liver diagnosis. 3 days ago · FIB-4 measures liver enzyme levels, which can generate false-positive results in patients with acute hepatitis independent of the degree of liver fibrosis 4. ) Die neue, gemeinsame Leitlinie der europäischen Leber/Diabetes/Adipositas-Gesellschaften (EASL/EASD/EASO) zum Management der MASLD führt den FIB4-Score als nicht-invasiven Parameter auf und bietet eine Strategie zur Beurteilung und zum weiteren Vorgehen. Fibrosis-4 (FIB-4) Calculator Share The Fibrosis-4 score helps to estimate the amount of scarring in the liver. Feb 1, 2022 · This review evaluates the ability of the fibrosis index based on four factors (FIB-4) identifying fibrosis stages, long-time prognosis in chronic live… The FIB-4 score is a non-invasive index used to assess liver fibrosis severity, and it is calculated using the FIB-4 formula: FIB-4 = (Age * AST) / (Platelet count * √ALT) The FIB-4 score provides valuable information to healthcare professionals for assessing the degree of liver fibrosis and cirrhosis. The APRI Score will appear in the oval on the far right (highlighted in yellow). 7%. Für die Berechnung des FIB4-Score werden lediglich das Al-ter, die Thrombozytenzahl sowie ALT und AST benötigt. A good fibrosis score typically indicates minimal to no liver fibrosis. APRI, FIB-4, and FIB-5 scores of patients who underwent liver biopsy due to CHB were calculated by means of calculators and recorded to be compared with liver biopsies in terms of fibrosis scoring. FIB-4 oder NAFLD Fibrosis Score (NFS), können bereits im Rahmen des Screenings eingesetzt werden, um eine Risikokonstellation (fortgeschrittene Fibrose) zu identifizieren. Jan 8, 2024 · In der aktualisierten S2k-Leitlinie NAFLD der DGVS erscheint der FIB-4 Score wegen seiner Einfachheit (er lässt sich automatisch aus den Routine-Labordaten ALAT, ASAT und Thrombozyten berechnen) geeignet, in allen ärztlichen Praxen Risiko-Patienten mit NAFLD zu identifizieren. Fibrosis-4-Index (FIB-4) Abnormal LFTs inc Fib4 Score Information This guidance has been developed specifically for use in primary care within NHS Lothian. 3 indicates a low risk for significant fibrosis Nov 18, 2020 · Ein Artikel aus dem Bereich gastroenterologie von GPnotebook: FIB-4-Index zum Ausschluss einer fortgeschrittenen Leberfibrose bei NAFLD. Jan 7, 2026 · The FIB-4 score is based on AST and ALT levels, age and platelet count, which you’ll find on a standard CBC (complete blood count), she explains. Why is FIB-4 used in NAFLD? You may have heard that FIB-4 scores are most often used in the clinical setting of non-alcoholic steatohepatitis. The FIB-4 Index is a blood-based diagnostic test that looks at underlying fibrosis that can be used as a measure to help determine NAFLD/NASH status. Studies have shown that the FIB-4 score has good accuracy in identifying individuals with significant fibrosis or cirrhosis, especially in patients with chronic viral hepatitis, non-alcoholic fatty liver disease (NAFLD), and alcoholic liver disease. May 19, 2025 · Abstract . 61%, respectively) in patients with severe liver fibrosis (stages 3 and 4). 67, advanced fibrosis is likely, though it is reasonable to still further assess with subsequent non-invasive testing for confirmation. The Fibrosis-4 (FIB-4) Index for Liver Fibrosis is a non-invasive scoring system based on several laboratory tests that help to estimate the amount of scarring in the liver. They should be essential in everyday clinical decision making. Die Serumbasierten Tests sind gut ge-eignet, um eine fortgeschrittene Fibro-se auszuschließen und zudem auch leicht verfügbar. Oct 1, 2019 · NAFLD Fibrosis Score Angulo et al. 30 (No to minimal fibrosis) A FIB-4 score within the F0-F1 range suggests a low likelihood of significant fibrosis or cirrhosis. 3 to 2. Use of the FIB-4 score in risk-stratification of patients with MASLD is predicated on its high negative predictive value (i. Sind diese Scores nor mal, ist eine fortgeschritten Leberfibrose (F3/F4) sehr unwahrscheinlich. Your doctor may also perform a liver biopsy or imaging tests to diagnose liver disease if needed like: We would like to show you a description here but the site won’t allow us. If the person is at high risk of advanced liver fibrosis, refer to a hepatology specialist for further assessment and management. of perinatal transmission, and its chronicity contributes to the disease burden seen in adults. In patients with a FIB-4 score of greater than 2. Although the FIB-4 score is a useful screening tool, it cannot definitively diagnose NASH or distinguish between different liver diseases. (Repeat testing every 2 years is suggested for patients with a low FIB-4 index. Er wird insbesondere bei chronischen Lebererkrankungen (z. g. Avoid calculating FIB-4 during acute hepatic inflammation or flares of chronic liver disease. Sind diese Scores normal, ist eine fortgeschrittene Leberfibrose (F3/F4) sehr unwahrscheinlich. Regeln: Bei einem FIB4-Score ≤ 1,30 (< 2,0 bei Patienten mit 65 Jahren und älter) wird ein niedrigeres Risiko für eine Leberfibrose angenommen und abhängig vom klinischen Risiko eine Kontrollbestimmung Aug 30, 2024 · ESC Clinical Practice Guidelines aim to present all the relevant evidence to help physicians weigh the benefits and risks of a particular diagnostic or therapeutic procedure on Atrial Fibrillation. Dec 8, 2023 · QR-Codes links). The risk of cardiovascular disease should be assessed using a validated tool. It is unclear how noninvasive tests (NITs) accurately correlate to liver biopsy. * Multi-language feature * Application starts with language with device language (CurrentCulture) automatically * Right-to-Left flow for Arabic like languages. NAFLD Fibrosis Score (NFS) — an intermediate or high score (greater than minus 1. Der FIB-4-Score ist ein laborbasierter Score zur Abschätzung des Leberfibrosegrades. If repeat FIB4 scores >1. This NAFLD fibrosis score calculator stratifies the degree of fibrosis to the liver in nonalcoholic fatty liver disease patients by assigning a specific stage. Your local guidance may differ. Please note: The use of the FIB-4 score is not validated where a patient is over 75 years of age. The aim of this study was to characterize patients with metabolic-associated steatotic liver disease who underwent liver biopsy in South Texas an … Policy Scope of Policy This Clinical Policy Bulletin addresses non-invasive tests for hepatic fibrosis. Aug 5, 2025 · Unpack the FIB-4 score to understand its role in assessing liver health and interpreting your results for informed next steps. An FIB-4 index >1. We present initial Results of a pilot of case-finding for NAFLD in T2DM patients in a GP practice in the North East of England using Fib4 scores, in order to assess the likely cost implications of such screening in the community. FIB-4 and APRI scores were strongly correlated to liver stiffness measurement scores by TE, and the correlation index was 81. kleines Blutbild und kann daher auch im Rahmen der vertragsärztlichen Versorgung durchgeführt werden. Feb 5, 2024 · FIB-4-Index zur Vorhersage von leberbezogenen und kardiovaskulären Ereignissen bei Adipositas und Typ-2-Diabetes FIB-4 index for prediction of liver-related and cardiovascular events in obesity and type 2 diabetes Journal Club Published: 05 February 2024 Volume 20, pages 290–292, (2024) Cite this article Download PDF S. The FIB-4 index, originally developed for detecting Aug 30, 2024 · Guidelines evaluate and summarize available evidence with the aim of assisting health professionals in proposing the best diagnostic or therapeutic approac Dec 17, 2023 · Patient with FIB-4 of 1. It's very simple and with your mobile you can easily calculate. e. Management of NAFLD in primary care includes: We would like to show you a description here but the site won’t allow us. The FIB-4 index is the preferred noninvasive initial test to assess the risk of NAFLD with liver fibrosis. FIB-4 score of 1. 67: high risk. B. While originally developed to detect liver fibrosis among patients with Hepatitis C and HIV, FIB-4 scoring has been increasingly used by the diabetes and NAFLD/NASH communities. Daher wird in diesem Kapitel nur auf die Veränderungen der Leitlinie des Hepatozellulären Karzinoms eingegangen. * Default language is English (en-US) Apr 25, 2025 · Liver biopsy is the gold standard for quantifying steatosis and fibrosis. Feb 18, 2025 · This updated systematic review and meta-analysis provides the most comprehensive data on the diagnostic accuracy of APRI, FIB-4 and FibroScan for staging liver fibrosis and cirrhosis in patients with chronic hepatitis B. ” A score less than 1. Zur Bestimmung des Fettgehalts der Le-ber kann der Fettleber-Index (FLI) einge-setzt werden. 30 then refer to hepatology clinic Abnormal LFT pathway: Created Jan 2024 Dr. The risk of advanced liver fibrosis should be assessed using a non-invasive scoring system, such as the NAFLD Fibrosis Score (NFS), Fibrosis (FIB)-4 score or the Enhanced Liver Fibrosis (ELF) test. B. 5 had a positive predictive value of 95. “You can quickly find a FIB-4 calculator online, enter your numbers and see where you stand. FIB-4 score higher than 2. The APRI and FIB-4 scores had a good accuracy to exclude significant fibrosis in chronic hepatitis B virus infection. Der FIB4-Score (Fibrose-Score aus 4 Werten errechnet) dient der Beurteilung einer potenziellen Leberfibrose bei MASLD (Metabolic dysfunction-associated steatotic liver disease). The source for medical equations, algorithms, scores, and guidelines. Sathyanarana Hepatology Consultant Barnsley Hospital We would like to show you a description here but the site won’t allow us. Bei einem FIB4-Score ≤ 1,30 (< 2,0 bei Patienten mit 65 Jahren und älter) wird ein niedriges Risiko für eine Leber- fibrose angenommen und abhängig vom klinischen Risiko eine Kontrollbestimmung des FIB4-Tests in 2-5 Jahren empfohlen. Based on these results, an APRI score greater than 0·5 or a FibroScan value greater than 7·0 kPa for significant fibrosis ARFI, acoustic radiation force impulse; ELF, enhanced liver fibrosis; FIB-4, fibrosis-4; HCC, hepatocellular carcinoma; NAFLD, non-alcoholic fatty liver disease; NFS, NAFLD Fibrosis Score. 3 or greater should undergo secondary risk assessment. FIB-4 enables not only early detection of liver fibrosis but also identification of patients at high cardiovascular risk. May 19, 2025 · Guidelines suggest that FIB-4 values >1. Un FIB4 ≤ 1,45 a une valeur prédictive négative de 93,7% et un FIB4 > 4 a une valeur prédictive positive de 66%. Le score Fibrosis-4, ou FIB4 peut correctement identifier les malades avec une fibrose sévère (F3-F4). Some patients identified with potential fibrosis using Fib-4 did not attend specialist follow up and represent a missed opportunity for intervention. Feb 13, 2017 · The FIB 4 and NAFLD Fibrosis Score models had a high negative predictive value (93. We would like to show you a description here but the site won’t allow us. Die diagnostische Wertigkeit für den Ausschluss einer fortgeschrittenen Leberfibrose ist für den NFS und FIB-4 Index vergleichbar, wobei dem FIB-4 weniger Parameter zugrunde liegen. Nov 7, 2025 · Learn how the FIB-4 Index uses AST, ALT, platelets, and age to estimate liver fibrosis risk—plus how to self-calculate without charges. The FIB-4 score is calculated using the patient's age, AST, ALT, and platelet count, and it helps clinicians determine the degree of fibrosis in the liver. Fibrosis (FIB)-4 Score (FIB-4) — a score of greater than 2. Beide setzen sich aus einfach zu Score mithilfe verschiedener Webtools ein-fach berechnen. reliably excluding AF). In the context of the FIB-4 index, which assesses liver fibrosis severity, the following ranges are used: - F0-F1: FIB-4 score < 1. Feb 12, 2025 · Der FIB4-Score errechnet sich aus den Parametern GOT, GPT, der Thrombozytenzahl und dem Alter. Jun 25, 2025 · Hierbei können Serumbasierte Scoring-Systeme (z. Hepatitis serology- Hepatitis B and C Autoimmune liver screen- Anti-smooth muscle antibody, Anti-nuclear antibody, Anti-LKM1, Anti-mitochondrial antibody Fib4 score Should be used to aid referral decision and is calculated from the patient's blood tests and examination findings. untersuchten eine Kohorte von 733 Patienten mit nichtalkoholischer Fettlebererkrankung und entwickelten den NAFLD Fibrosis Score (NFS), der auf Alter, Hyperglykämie, BMI, Thrombozytenzahl, Albumin und AST-ALT-Ratio basiert, als Prädiktor für fortgeschrittene Fibrose (F3 bis F4; [7]). Fibrose [FIB]4-Score) von bildgebenden Verfahren zur Bestimmung der Leberelastizität (z. The FIB-4 score is a widely used non-invasive index for assessing liver fibrosis severity. Zur Klärung der entschei-denden Frage, ob es bereits zu einer rele-vanten Fibrosierung der Leber gekommen ist, stehen verschiedene nichtinvasive Scores zur Verfügung. 48% and 93. FIB-4 Calculator for NAFLD NB This is only valid for non-alcoholic fatty liver disease (NAFLD) and is intended for use in conjunction with the NCL Abnormal LFT pathway. The score performs poorly in patients younger than 35 years and may require adjusted cutoffs 2. die transiente Elastografie oder Scherwellenelastografie) unterschieden werden. fie zur Verfügu g (Berechnung der Scores s. Die US-Gastroenterologen geben jetzt sehr konkrete Management-Empfehlungen. This fibrosis 4 (FIB4) score calculator reveals whether there is significant liver fibrosis of different stages associated to cirrhosis using patient age, AST & ALT. 3. Sep 25, 2025 · Your risk score, known as the Fibrosis-4 (FIB-4) Index, means the following: FIB-4 score less than 1. There are multiple online tools to help calculate the Fib4 score. Siddiqui et al. Kardiologie, Diabetologie, Pädiatrie) sowie Patient:innenvertretern [2 Der FIB-4-Score ist ein laborbasierter Score zur Abschätzung des Leberfibrosegrades. Der FIB4-Test beruht auf den Basislaborleistungen GOT, GPT und Thrombozytenzahl bzw. Oct 28, 2022 · A 2-step approach, Fibrosis-4 index (FIB-4) followed by vibration-controlled transient elastography (VCTE), has been proposed to predict advanced fibrosis in patients with nonalcoholic fatty liver Nov 16, 2025 · Using FIB-4 in acute inflammation: The score incorporates AST and ALT, which can be elevated in acute hepatitis, leading to falsely elevated scores 1 Relying on FIB-4 alone for diagnosis: A high score requires confirmatory testing; it is not diagnostic by itself 1, 2 Jul 9, 2025 · The FIB-4 (Fibrosis-4) Index is a simple, non-invasive scoring system that uses a patient's age and three standard blood tests (AST, ALT, and platelet count) to estimate the severity of liver fibrosis. Methods 76 successive patients attending their GP practice for routine diabetic review had a Fib4 score calculated. In der Leitlinie empfohlen werden in erster Linie FIB-4 (Fibrosis 4) oder NFS (NAFLD Fibrosis Score). Nov 16, 2025 · Using FIB-4 in acute inflammation: The score incorporates AST and ALT, which can be elevated in acute hepatitis, leading to falsely elevated scores 1 Relying on FIB-4 alone for diagnosis: A high score requires confirmatory testing; it is not diagnostic by itself 1, 2 May 19, 2025 · Abstract . , FibroScan) medically necessary for follow-up of primary sclerosing cholangitis, monitoring of liver function in Wilson's disease, and for distinguishing hepatic cirrhosis from non-cirrhosis in persons with hepatitis B, hepatitis . Bisher besteht nur eine Leitlinie zur Diagnostik und Therapie des Hepatozellulären Karzinoms (HCC). Dec 18, 2023 · The results of this study confirm the prognostic utility of FIB-4 for risk of subsequent liver-related events, with a high risk of incident liver events in groups with FIB-4 scores indicating high and indeterminate risk of advanced fibrosis. Der FIB4-Score ist ein sehr guter Parameter, um fortgeschrittene Fibrosen serologisch zu identifizieren. a. 3: low risk. Die diagnostische Wertig keit des NFS und des FIB 4 Scores sind für den Aus schluss einer fortgeschrittenen Leberibrose ver gleichbar, der FIB 4 Score beinhaltet aber weniger Pa We would like to show you a description here but the site won’t allow us. FIB-4 is less reliable in patients under the age of 35 or over the age of 65. E Stellenwert von Biomarkern für das NAFLD Screening (S2k-Leitlinie) Nicht-invasive Scores, z. General practitioners may choose to use it when mildly abnormal LFTs results have been found in asymptomatic patients. 2% to consider fibrosis with a sensitivity of 85. 67 suggests advanced liver fibrosis. 455), suggests advanced liver fibrosis. Der FIB-4 ist somit einfacher zu bestimmen, kostengünstiger und sollte vorrangig verwendet werden (S2k-Leitlinie). 67: medium risk. Enter the required values to calculate the FIB-4 value. Most experts recommend using 40 IU/L as the value for the AST upper limit of normal when calculating an APRI value. Regeln: Bei einem FIB4-Score ≤ 1,30 (< 2,0 bei Patienten mit 65 Jahren und älter) wird ein niedrigeres Risiko für eine Leberfibrose angenommen und abhängig vom klinischen Risiko eine Kontrollbestimmung We would like to show you a description here but the site won’t allow us. Die bildgebenden Verfahren sind wiederum besser geeig-net, eine fortgeschrittene Fibrose zu er-kennen. FIB-4 y APRI, métodos no invasivos de predicción de la fibrosis hepática We would like to show you a description here but the site won’t allow us. It will appear in the oval on the far right (highlighted in yellow). Die überragende epidemiologische Bedeutung und die zuneh-mende wissenschaftliche Basis zum Management der NAFLD waren entscheidende Beweggründe für die Erarbeitung einer aktualisierten deutschen S2k-Leitlinie zur NAFLD unter Federfüh-rung der DGVS und unter Mitbeteiligung von 16 weiteren Fachge-sellschaften (u. Conclusions Fib-4 score on discharge was superior to Fib-4 score on admission. Die diagnostische Wertigkeit des NFS und des FIB-4-Scores sind für den Ausschluss einer fortgeschrittenen Leberfibrose vergleichbar, der FIB-4-Score beinhaltet aber weniger Parameter und ist deshalb einfacher zu erheben. FIB-4: Bridging liver fibrosis with cardiovascular risk and proactive preventionBackground. The lower-than-expected NPV observed highlight limitations of FIB-4 in MASLD. The association between the Fibrosis-4 (FIB-4) index and the occurrence of MACCEs, as well as the association between the Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) scores and MACCEs, were evaluated. 4–96. The FIB-4 index, originally developed for detecting Bei einem FIB4-Score ≤ 1,30 (< 2,0 bei Patienten mit 65 Jahren und älter) wird ein niedriges Risiko für eine Leber- fibrose angenommen und abhängig vom klinischen Risiko eine Kontrollbestimmung des FIB4-Tests in 2-5 Jahren empfohlen. Kahl 125 Accesses We would like to show you a description here but the site won’t allow us. QR Codes links). 3 warrant intensified management of metabolic and cardiovascular comorbidities such as hypertension, diabetes, and dyslipidemia.

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